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Massachusetts General Hospital researcher Hyon K. Choi, MD, DrPH, and
colleagues collected data on more than 47,000 middle-aged men for 12 years. The
more weight the men gained, the higher their risk of gout. But over the course
of the study, those who lost weight cut their gout risk.
"Weight loss greater than 10 pounds since the 1986 study baseline was associated
with a substantially reduced risk of gout," Choi and colleagues report. "Our
study is the first to document this important potential benefit of weight
loss."
The findings appear in the April 11 issue of Archives of Internal Medicine .
More Pounds, More Gout Risk
Gout attacks when there's too much uric acid in the body. This makes one's
joints fill up with uric acid crystals. The joints swell and are very painful.
Attacks usually go away in a few days but return with greater frequency and
severity if not treated. Gout is more common in men, and it usually strikes
during middle age.
Drinking alcoholic beverages is bad for gout because it raises uric acid
production and slows its elimination. Foods rich in substances called purines
-- especially those found in some meats and seafood -- also contribute to gout.
But Choi's team finds that whatever their diet, men who gain weight get gout
more often. Compared with men who don't gain weight, overweight men ( body mass
index or BMI body mass index or BMI of at least 25) are more than twice as
likely to develop gout -- and obese men have triple the gout risk.
Men who gained 30 pounds or more since age 21 had twice the gout risk of men who
didn't gain weight during adulthood.
Losing weight may help. Men who lost 10 pounds or more dropped their gout risk
by 40%.
High Blood Pressure, Water Pills Also Play Role
But weight isn't the only risk factor. Choi and colleagues also found that
having high blood pressure ups gout risk as much as being overweight. And using
water pills (diuretics) also nearly doubled gout risk.
"Our findings are most directly generalizable to men over 40 years and older ...
with no history of gout," they write. "Whether these findings apply to women or
to men with existing gout remains to be studied."
By Daniel DeNoon
Reviewed By Kathleen Zelman, MPH, RD, July 25, 2007.
Medically updated July 25, 2007.
SOURCE: Choi, H. Archives of Internal Medicine , April 11,
2005; vol 165: pp 742-748.
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